| Granulosa cell tumour | |
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| Classification and external resources | |
Micrograph of a juvenile granulosa cell tumour with hyaline globules. H&E stain. |
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| ICD-10 | C56 |
| ICD-9 | 183 |
| ICD-O: | 8620 |
| eMedicine | med/928 |
| MeSH | D006106 |
Granulosa cell tumours (or granulosa-theca cell tumours) are tumours that arise from granulosa cells. These tumours are part of the sex cord-gonadal stromal tumouror non-epithelial group of tumours. Although granulosa cells normally occur only in the ovary, granulosa cell tumours occur in both ovaries and testicles (see Ovarian cancer and Testicular cancer). These tumours should be considered malignant and treated in the same way as other malignant tumours of ovary. The staging system for these tumours is the same as for epithelial tumours and most present as stage I[1]. The peak age at which they occur is 50–55 years, but they may occur at any age.
Juvenile granulosa cell tumour is a similar but distinct rare tumour. It too occurs in both the ovary and testis. In the testis it is extremely rare, and has not been reported to be malignant.[2] Although this tumour usually occurs in children (hence its name), it has been reported in adults.[3]
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Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age and sex.
Using next generation DNA sequencing, it was discovered that 97% of granulosa cell tumours contain an identical mutation in the FOXL2 gene [1]. This is a somatic mutation meaning it is not usually transmitted to descendants. It is believed that this mutation may be the cause of granulosa cell tumours.
Inhibin, a hormone, has been used as tumor marker for granulosa cell tumor.
In the ovaries of aging squirrel monkeys (Saimiri sciureus), clusters of granulosa cells occur that resemble granulosa cell tumours in humans.[4] These appear to be a normal change with age in this species.
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